منابع مشابه
Anticonvulsive properties of pregnanolone emulsion compared with althesin and thiopentone in mice.
The anticonvulsive properties of pregnanolone (as an emulsion) were evaluated in mice and compared with similar properties of Althesin and thiopentone. Pregnanolone emulsion was found to antagonize convulsions induced by the GABA antagonists pentetrazole, bicuculline and picrotoxin and by the specific glycine receptor antagonist, strychnine. The drug was effective in all four convulsive tests a...
متن کاملPregnanolone sulfate promotes desensitization of activated NMDA receptors.
Neurosteroids are potent neuromodulators which act in part by binding to and modifying the activity of neurotransmitter-gated channels. Pregnanolone sulfate (PAS) is an endogenous neurosteroid that inhibits NMDA receptors and is neuroprotective in vivo. To delineate the mechanism of NMDA receptor inhibition by pregnanolone sulfate we used kinetic analyses of equilibrium single-channel currents ...
متن کاملPregnanolone isomers, pregnenolone and their polar conjugates around parturition.
The levels of four pregnanolone isomers and their polar conjugates and pregnenolone sulfate were measured in the plasma of 13 and 7 women at delivery with subarachnoidal and epidural analgesia, respectively, and in corresponding samples of umbilical plasma using a simple quadrupole GC/MS system with electron impact ionization (pregnenolone isomers), RIA following HPLC separation (pregnenolone) ...
متن کاملRapid gas chromatographic assay for pregnanolone in pregnancy urine.
GAS CHROMATOGRAMS of chloroform extracts of hydrolyzed pregnancy urine have a characteristic appearance (1). Three major peaks appear regularly and are thought to be associated with a group of li-desoxy17-oxosteroids, with pregnanolone, and with preglianediol, respectively. During a study of the effect of acid concentration 011 the rate of hydrolysis of urinary pregnanediol glucuronide, it was ...
متن کاملCharacterization of discriminative stimulus effects of the neuroactive steroid pregnanolone.
Reduced pregnane neurosteroids such as allopregnanolone and pregnanolone are potent neuromodulators able to affect a number of membrane receptors, including gamma-aminobutyric acid (GABA)(A), N-methyl-D-aspartate (NMDA), 5-hydroxytryptamine (5-HT)(3), and sigma(1) receptors. The present study used a drug discrimination procedure to assess further the receptor effects of pregnanolone in vivo. Ra...
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ژورنال
عنوان ژورنال: Anaesthesia
سال: 1987
ISSN: 0003-2409,1365-2044
DOI: 10.1111/j.1365-2044.1987.tb03080.x